ImageXpress Micro 4

Widefield imaging for basic research through to high-content screening

The ImageXpress Micro 4 High-Content Imaging System is a high-throughput, widefield imager that can acquire images of whole organisms and cellular or intracellular events. It features proprietary fast frame rate technology, allowing for the capture of fast biological processes such as calcium oscillations in cardiomyocytes. It is highly configurable and adaptable to changing research needs. Available options include confocal, brightfield, phase contrast, liquid handing, and environmental control.

Expandable

Support many cellular assays

Image an incredible range of assays with various user-changeable filter cubes, 1-100x objectives, environmental control, fluidics option, and many sample formats including atypical plates for 3D assays.

Analyze images of more applications

A selection of feature-rich turnkey application modules is available with MetaXpress software. For the development of novel assays, we offer an optional custom analysis module.

Tailor the system to meet your needs

The imager is a highly flexible solution, you can add or change many of the components as your research priorities change. Examples include enhance light engines and automation.

Ordering information

Our experienced scientific teams are available whenever you have support inquiries, issues, and requests for applications or technical information. When you’re ready to take your research to the next level, our applications scientists, trained in the latest technological advancements and assay development techniques, will help get you there.

MetaXpress High-Content Image Acquisition and Analysis Software:

• MDCStore High Content Data Management Solution (included)
• Standard licensing is transferable to the computer of choice
• Network licensing allows multiple users to simultaneously connect to software
• AcuityXpress Informatics Software, data visualization, mining, and hit selection are ready to use upon system installation

MetaXpress PowerCore High-Content Distributed Image Analysis software for high-throughput image analysis:

• Various licensing is available to satisfy multiple parallel processes

MetaXpress software application modules:

• Optional modules can be added to the MetaXpress software license

The ImageXpress Micro 4 High-Content Imaging System represents the culmination of four generations of imaging expertise. The latest agile design allows you to boost your research with this faster-thanever system, while providing the option to upgrade to confocal in the future to align with your research needs.

Combined with MetaXpress High-Content Image Acquisition and Analysis Software, the ImageXpress Micro 4 system provides you with an intelligent, multi-dimensional, high-throughput screening solution to help you discover your next landmark scientific breakthrough.

Key features

Widefield imaging with digital confocal imaging

Field upgradeable to AgileOptix™ confocal technology

Large field of view captures 1.97 mm2 at 10X

> 3 log dynamic range

Acquire from a variety of multi-well plate formats up to 1536 including unusual formats developed for 3D assays with round bottom or trans-well plates

4 position objective changer and 5 position filter cube changer

High speed laser and image autofocus

Simplified Z stack acquisition and analysis

Widest selection of objectives

• 1x to 100x magnification
• Air objectives: up to 0.95 NA
• Oil objectives: up to 1.4 NA

Fully automated X-Y and Z stages with resolution better than 100 nm

Features

Multiple imaging modes

The system offers fluorescence, confocal, widefield, colorimetric, phase contrast, and brightfield label-free imaging.

Field upgradeable to confocal

The system can be upgraded to include the proprietary AgileOptix technology for accurate 3D volumetric analyses.

Wide dynamic range

Low and high intensity signal quantification in a single image with >3 log dynamic range intensity detection.

High speed image acquisition

Using 4x magnification with a 1536-well plate, 225K wells per day can be acquired. Greater than a million wells per week can be imaged.

Optional environmental control

Temperature, humidity, and CO2 control for multi-day live-cell imaging or fast kinetic studies are available.

Large magnification range

Air and oil immersion objectives ranging from 1x to 100x are available for installation into the 4-position objective changer.

Acquisition

Place a microplate or slide into the system. After a few clicks in the software, the system will run automatically and allow users to walk away.

Analysis

Immediately view results, which are automatically extracted from images in various formats including image montages, bar graphs, tables, scatter plots, and movies. The system can run and analyze over 25 preconfigured protocol templates.

Answers

Export and share data and images for presentations and publications with the built-in sharing and remote access capabilities. The system supports a multi-user environment and can be accessed and operated online via Chrome or Safari.